Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capillary blood viscosity in microcirculation.

A Cortinovis1, A Crippa, R Cavalli

  • 1Dipartimento di Medicina Interna e Terapia Medica, Sez di Clinica Medica 2, Università degli Studi di Pavia, IRCCS Policlinico S. Matteo, Italy.

Clinical Hemorheology and Microcirculation
|August 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of different doses of recombinant equine chorionic gonadotropin on follicular dynamics and blood perfusion in Holstein donors subjected to synchronization protocols for OPU.

Theriogenology·2026
Same author

Effect of recombinant equine chorionic gonadotropin on fertility of lactating dairy cows.

Theriogenology·2026
Same author

A data fusion approach unveils the effects of 3-nitrooxypropanol on the rumen fluid and milk metabolomes of lactating Holstein dairy cows.

Journal of dairy science·2026
Same author

Dominant follicle blood flow at the onset of proestrus does not affect steroid hormones, endometrial receptors, or follicular perfusion in beef cows under FTAI treatment regimens.

Theriogenology·2025
Same author

Effects of intramammary infection and dry-off treatment on the immune-metabolic profile of Alpine dairy goats.

Journal of dairy science·2025
Same author

Effects of 3-nitrooxypropanol on enteric methane emissions and milk production characteristics in dairy cows fed a high corn-silage diet in different environmental conditions.

Journal of dairy science·2025
Same journal

Suppression of macrophage enriched miRNA 210-3p improves cardiac fibrosis and cardiac function following myocardial infarction.

Clinical hemorheology and microcirculation·2026
Same journal

Downregulation of PCAF inhibits vascular smooth muscle cells senescence by reducing oxidative stress injury via activating the Nrf2/ARE pathway.

Clinical hemorheology and microcirculation·2026
Same journal

Blood viscosity values for predicting pathological stroke types (ischemic stroke, hemorrhagic stroke, and stroke mimic) at DR. Cipto Mangunkusumo National Referral Hospital.

Clinical hemorheology and microcirculation·2026
Same journal

Adaptations of blood fluidity markers to progressive resistance training in men.

Clinical hemorheology and microcirculation·2026
Same journal

Changes in whole blood viscosity in patients undergoing percutaneous or surgical intervention for aortic stenosis.

Clinical hemorheology and microcirculation·2026
Same journal

Impairment of cutaneous microcirculation and vasoreactivity in primary hypothyroidism.

Clinical hemorheology and microcirculation·2026
See all related articles

Capillary blood viscosity, not arteriolar resistance, significantly impacts blood flow. Measuring capillary blood viscosity and general blood viscosity offers insights into erythrocyte deformability and aggregate characteristics for improved circulation.

Area of Science:

  • Hemodynamics
  • Biophysics
  • Cardiovascular Physiology

Background:

  • Arteriolar resistance, characterized by high shear-rate and low viscosity, accounts for a significant pressure fall (50 mmHg).
  • Capillary resistance involves lower shear-rates and a lower pressure fall (11.5 mmHg), where blood viscosity becomes more dominant.
  • Capillary Blood Viscosity (CBV) is influenced by rheological and structural blood properties, unlike arteriolar resistance.

Purpose of the Study:

  • To investigate the role of Capillary Blood Viscosity (CBV) in determining pressure fall at the capillary level.
  • To measure General Blood Viscosity (GBV) and CBV at low shear-rates using a model simulating capillary networks.
  • To establish CBV as a key factor for improving capillary blood flow and assess erythrocyte deformability.

Main Methods:

Related Experiment Videos

  • Developed an experimental model replicating capillary district structures.
  • Measured General Blood Viscosity (GBV) and Capillary Blood Viscosity (CBV) at low shear-rates.
  • Calculated erythrocyte deformability from the ratio of GBV to CBV.

Main Results:

  • Capillary Blood Viscosity is the dominant resistance factor at the capillary level, despite lower overall pressure fall.
  • The ratio of GBV to CBV provides a quantitative measure of erythrocyte deformability.
  • RBC aggregate size and stability influence endothelial thrombo-resistance and cell adhesion.

Conclusions:

  • Changes in Capillary Blood Viscosity are the primary clinical strategy for enhancing capillary blood flow.
  • Arteriolar interventions may not effectively improve capillary flow and could activate arterio-venous shunts.
  • Assessing RBC aggregation provides insights into systemic circulation, cell adhesion, and thrombo-resistance.