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Updated: Aug 6, 2026
Developing a Clinically Relevant Hemorrhagic Shock Model in Rats
Published on: March 22, 2024
Hemorheological disorders in the microcirculation during septic shock in rats
Tea Sordia1, Jemal Tatarishvili, George Mchedlishvili
1Microcirculation Research Center, I. Beritashvili Institute of Physiology, 14 Gotua St., 0160, Tbilisi 0160, Georgia. tiko_sordi@yahoo.com
Objectives:
The aim of the present study was the experimental analysis of blood rheological disorders in the microcirculation during endotoxic shock.
Methods:
Experiments were carried out on 30 white laboratory rats of both sexes weighing about 200 g. The experimental animals were divided in two groups: the control group and the group undergoing experimental endotoxic shock. The following specific hemorheological properties were investigated in all animals during the experiments: red blood cells (RBC) aggregability, their deformability and the systemic hematocrit.
Results:
We found that all the investigated hemorheological parameters appreciably changed underconditions of endotoxic shock. The RBC aggregability index was increased by a mean of 136%. As to the RBC deformability index was found to be decreased by 71%, and the systemic hematocrit lowered by 31%, as compared to the same parameters in the control group.
Conclusion:
The data obtained provide us with evidence that the hemorheological derangements associated with the development of the heavy microcirculatory disorders during endotoxic shock, are most significant factors.
