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A Simplified Technique for In situ Excision of Cornea and Evisceration of Retinal Tissue from Human Ocular Globe
Published on: June 12, 2012
Preserving the cornea: corneal storage media
1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. jengb@ccf.org
Current Opinion in Ophthalmology
|August 11, 2006
Summary
Corneal storage media research is advancing, focusing on preserving both endothelium and epithelium for longer graft survival. New developments aim to optimize storage solutions for improved outcomes in corneal transplantation.
Area of Science:
- Ophthalmology
- Transplantation Science
- Biomaterials Science
Background:
- Corneal transplantation relies on effective storage media for donor tissue viability.
- Traditional organ culture methods are still prevalent in Europe, while Optisol GS dominates in the US.
- Persistent epithelial defects post-transplantation highlight the need for improved epithelial preservation.
Purpose of the Study:
- To review recent literature on corneal storage media.
- To discuss advancements in media composition and preservation techniques.
- To identify future research directions in corneal storage.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of trends in corneal storage media usage and development.
- Synthesis of findings on endothelial and epithelial cell preservation.
Main Results:
- Optisol GS remains a popular choice in the US; organ culture persists in Europe.
- Increased focus on preserving corneal epithelium, not just endothelium.
- Research into antimicrobial prophylaxis for donor corneas is growing.
Conclusions:
- Corneal storage media require optimization for extended endothelium preservation, potentially improving high-risk graft outcomes.
- Developing methods to sustain corneal epithelium beyond one week is crucial.
- Future research should prioritize longer-term preservation of both corneal layers.
