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Dementia lacking distinctive histology (DLDH) revisited

Ian R A Mackenzie1, Jing Shi, Catherine L Shaw

  • 1Department of Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

Acta Neuropathologica
|August 11, 2006
PubMed
Summary

Improved ubiquitin immunostaining reclassified most "dementia lacking distinctive histology" (DLDH) cases as frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). This suggests DLDH is rare, with pathology often missed due to less sensitive staining methods.

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