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Rh alloimmunization: Doppler or amniotic fluid analysis in the prediction of fetal anemia?
Luciano Marcondes Machado Nardozza1, Antonio Fernandes Moron, Edward Araujo Júnior
1Obstetrics Department, UNIFESP-EPM, Av. Lopes de Azevedo, 888, São Paulo, SP, 05603-001, Brazil. lunardozza@uol.com.br
Objective:
Compare the results of amniocentesis and those of middle cerebral artery peak systolic velocity to detect anemic fetuses in Rh alloimmunized pregnancies.
Method:
Descriptive observational study involving 99 consecutive Rh-negative pregnancies: 74 alloimmunized patients submitted to amniotic fluid spectrophotometry (group 1) and 25 alloimmunized cases managed with Doppler ultrasonography (group 2). Variables analyzed were the following: need for neonatal transfusion and neonatal hematocrit.
Result:
Neonatal hematocrit was significantly lower and the need for neonatal transfusion was significantly higher in cases managed with spectrophotometry compared to those managed with Doppler.
Conclusion:
Infants managed with Doppler velocimetry had higher hematocrit and less need for neonatal transfusion, suggesting that this non-invasive method of monitoring fetal anemia may best preserve the neonate.
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