An implantable aortic valvo-pump for destination therapy

Area of Science:

• Biomedical Engineering
• Cardiovascular Devices
• Medical Implants

Background:

• Heart failure necessitates advanced circulatory support systems.
• Existing left ventricular assist devices (LVADs) often require complex bypass circuits.
• Improving antithrombogenicity and device integration is crucial for long-term LVAD application.

Purpose of the Study:

• To develop and evaluate a novel, compact implantable aortic valvo-pump.
• To assess the hemodynamic performance and potential antithrombogenicity of the device.
• To investigate the feasibility of a long-term applicable left ventricular assist device without external conduits.

Main Methods:

• Development of a 23 mm outer diameter, 31 g implantable aortic valvo-pump.
• The device integrates a rotor with impeller and a stator with motor coil and guide vane.
• Hemodynamic testing to measure blood flow and pressure generation at various speeds.

Main Results:

• The valvo-pump directly delivers blood from the left ventricle to the aorta, eliminating the need for bypass circuits.
• Achieved a blood flow of 7 L/min with a 50 mmHg pressure increase at 15,000 rpm.
• Maintained a diastolic pressure over 80 mmHg at zero flow rate and the same rotational speed.

Conclusions:

• The developed aortic valvo-pump demonstrates promising antithrombogenicity due to its direct integration.
• The device shows effective hemodynamic function, supporting its potential as a long-term heart assist solution.
• Further investigation into blood compatibility and device durability is essential for clinical translation.