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On estimating treatment effects under non-compliance in randomized clinical trials: are intent-to-treat or
Heejung Bang1, Clarence E Davis
1Division of Biostatistics and Epidemiology, Department of Public Health, Weill Medical College of Cornell University, New York, NY 10021, USA. heb2013@med.cornell.edu
Abstract:
In this report, we compared four estimators (intent-to-treat, as treated, per protocol, and instrumental variables estimators) that are conventionally considered for treatment effect estimation by simulation under different non-compliance scenarios in typical clinical trial settings. We found that intent-to-treat and instrumental variables estimators are not perfect and can be problematic in some situations although these two estimators carry desirable properties as we assume.
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