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A study of the association between delayed type hypersensitivity reaction to mycobacterium tuberculosis and atopy in

Mohamed T Omar1, Siham H Ahmed, Nadia N Sarkis

  • 1Pediatric Department, Damanhour Medical National Institute. nadawanas@yahoo.com

The Journal of the Egyptian Public Health Association
|August 12, 2006
PubMed

Insights

This study found no significant link between Mycobacterium tuberculosis infection and atopy in Egyptian children. Atopy prevalence was similar in children with and without tuberculosis infection.

Area of Science:

  • Epidemiology
  • Immunology
  • Pediatrics

Background:

  • Atopy, a predisposition to allergic diseases, and Mycobacterium tuberculosis infection are significant global health concerns.
  • Previous research suggests a potential inverse association between tuberculosis infection and atopy, but findings are inconsistent.

Purpose of the Study:

  • To investigate the association between Mycobacterium tuberculosis infection and atopy in children residing in rural and semi-urban areas of El Behira governorate, Egypt.

Main Methods:

  • A cohort of 150 children aged 4-8 years, all BCG vaccinated, were assessed.
  • Tuberculosis infection was determined by purified protein derivative (PPD) tuberculin testing (induration ≥5 mm positive).
  • Atopy was evaluated using skin intradermal testing with common aeroallergens (reaction ≥3 mm positive).

Main Results:

  • Of 150 children, 89 were PPD negative and 61 were PPD positive.
  • Atopy prevalence was 51.6% in PPD-negative children and 52.4% in PPD-positive children.
  • No statistically significant difference in atopy prevalence was observed between the PPD-positive and PPD-negative groups (p > 0.05).

Conclusions:

  • This study found no statistically significant association between Mycobacterium tuberculosis infection and atopy in the studied Egyptian pediatric population.
  • The findings suggest that BCG vaccination may influence the relationship between tuberculosis and atopy.
  • Further research is needed to elucidate the complex interplay between infectious diseases and allergic conditions.
Abstract

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