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[Effects of long-term and low-dose hormone replacement therapy on bone mineral density in postmenopausal women]
Min Nie1, Mei-Li Sun, Qin-Sheng Ge
1Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Objective:
To observe the effects of long-term and low-dose hormone replacement therapy on bone mineral density (BMD), and the incidence of bone pain in postmenopausal women.
Methods:
Totally 141 postmenopausal women were selected from the medical staff of the Peking Union Medical College Hospital. Of them, 63 women treated with low-dose sex hormone for over 5 (5-32) years were divided into hormone replacement therapy (HRT) group, and 78 never receiving HRT were divided into control group. The BMD was measured by dual energy X-ray absorptiometry (DEXA) at lumbar spine, Ward's triangle, femoral neck, trochanter, and total hip, and the incidence of bone pain was inquired.
Results:
The BMD in the HRT group was 9.1% higher than that in the control group (P < 0.05). The incidence of bone pain was significantly lower in the HRT group (71.4%) than that in the control group (89.7%).
Conclusion:
Long-term and low-dose hormone replacement therapy can reduce bone loss and the incidence of bone pain.
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