Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cyclic vomiting syndrome plus.

Richard G Boles1, Amy L R Powers, Kathleen Adams

  • 1Division of Medical Genetics, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA. rboles@chla.usc.edu

Journal of Child Neurology
|August 12, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

De Novo Variants Predominate in Autism Spectrum Disorder.

Genes·2025
Same author

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition 2025 guidelines on the diagnosis of cyclic vomiting syndrome in children.

Journal of pediatric gastroenterology and nutrition·2025
Same author

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition 2025 guidelines for management of cyclic vomiting syndrome in children.

Journal of pediatric gastroenterology and nutrition·2025
Same author

A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial.

International journal of molecular sciences·2025
Same author

Clinical outcomes of a twice-daily metronidazole dosing strategy for Bacteroides spp. bloodstream infections.

International journal of antimicrobial agents·2024
Same author

Cyclic vomiting syndrome: A patient/parent perspective.

Neurogastroenterology and motility·2024
Same journal

Genetic Etiologies and Risk Factors for Regressive Autism and Childhood Disintegrative Disorder: A Scoping Review.

Journal of child neurology·2026
Same journal

Birmingham, 1963.

Journal of child neurology·2026
Same journal

Hyperintensity on Diffusion-Weighted Imaging in a MELAS Patient Does Not Necessarily Mean Cytotoxic Edema.

Journal of child neurology·2026
Same journal

Neuromuscular Symptoms of <i>ORAI1</i>-Related Immunodeficiency.

Journal of child neurology·2026
Same journal

Symptoms of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, and Autism Spectrum Disorder in Children and Adolescents Attending a Headache Outpatient Clinic and School-Based Controls.

Journal of child neurology·2026
Same journal

Acute Encephalopathy From Central Nervous System Hemophagocytic Lymphohistiocytosis (CNS HLH) in X-Linked Lymphoproliferative Disease Type 1 (XLP-1).

Journal of child neurology·2026
See all related articles

Cyclic vomiting syndrome with neuromuscular disease (CVS plus) presents a distinct phenotype. It shows earlier onset and increased comorbidities, possibly linked to mitochondrial dysfunction.

Area of Science:

  • Neurology
  • Genetics
  • Pediatrics

Background:

  • Cyclic vomiting syndrome (CVS) is a disabling childhood condition with episodes of nausea and vomiting.
  • A subset of CVS patients (25%) exhibit coexisting neuromuscular disease, termed CVS plus.
  • The distinctiveness of CVS plus within the broader CVS spectrum requires investigation.

Purpose of the Study:

  • To determine if CVS patients with neuromuscular disease (CVS plus) represent a distinct subentity.
  • To compare clinical characteristics between CVS plus and CVS without neuromuscular disease (CVS minus).

Main Methods:

  • A clinical interview was conducted with 80 CVS sufferers from a disease association database.
  • Subjects were categorized into CVS plus (≥2 neuromuscular manifestations) and CVS minus (0 manifestations).

Related Experiment Videos

  • Neuromuscular disease manifestations were assessed, including cognitive, skeletal, cranial nerve, and seizure disorders.

    • Main Results:

    • Neuromuscular disease manifestations clustered together in subjects.
    • CVS plus patients had an earlier age of onset for vomiting episodes.
    • CVS plus showed a 3-8 fold increased prevalence of dysautonomia and constitutional disorders, but similar sibling recurrence of neuromuscular disease.

    Conclusions:

    • CVS plus represents a distinct phenotypic entity, not necessarily genetically distinct from CVS minus.
    • CVS plus predicts earlier disease onset and increased comorbidity with specific medical conditions.
    • Mitochondrial dysfunction may underlie the distinct phenotype observed in CVS plus.