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Published on: May 4, 2016
Genotoxicity testing of a Salacia oblonga extract
A M Flammang1, G L Erexson, M S Mecchi
1Ross Products Division Abbott Laboratories, 3300 Stelzer Road, 625 Cleveland Avenue, Columbus, OH 43215-1724, USA. ann.flammang@abbott.com
Summary
Salacia oblonga root extract shows potential for blood glucose control. While generally safe, further research is recommended due to a weak positive result in one genotoxicity test.
Area of Science:
- Phytochemistry
- Pharmacology
- Toxicology
Background:
- Salacia oblonga, used in Ayurvedic medicine for diabetes, inhibits intestinal alpha-glucosidases.
- This suggests potential for S. oblonga as a natural agent to manage blood glucose levels.
- Evaluation of novel ingredients for blood glucose control necessitates safety assessments.
Purpose of the Study:
- To evaluate the genotoxicity of Salacia oblonga root extract (SOE) as part of a safety assessment for food ingredients.
- To determine the safety profile of SOE for potential use in blood glucose management products.
Main Methods:
- Standard genotoxicity test battery recommended by the US FDA for food ingredients.
- Includes reverse mutation assay, chromosomal aberrations assay, and mouse micronucleus assay.
- Human lymphocytes were used for the chromosomal aberrations assay.
Main Results:
- SOE was not genotoxic in the reverse mutation assay and mouse micronucleus assay.
- SOE showed a weak positive result in the chromosomal aberrations assay in human lymphocytes.
- The positive chromosomal aberrations response was reproducible but weak.
Conclusions:
- SOE is not considered genotoxic under the tested conditions for two standard assays.
- A weak positive chromosomal aberrations response warrants further investigation and toxicity research.
- SOE is anticipated to be safe for consumption at expected intake levels, pending further research.
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