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Related Experiment Videos

Basophil releasability in human hydatidosis.

A Aceti1, D Celestino, M Caferro

  • 1Istituto di Clinica delle Malattie Tropicali e Infettive, Università La Sapienza, Roma, Italia.

International Archives of Allergy and Applied Immunology
|January 1, 1990
PubMed
Summary

Hydatidosis patients show increased histamine release from basophils when stimulated via immunoglobulin E (IgE). This suggests Echinococcus granulosus infection enhances basophil sensitivity to IgE-dependent triggers.

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Area of Science:

  • Immunology
  • Parasitology
  • Cellular Biology

Background:

  • Hydatidosis is a parasitic infection caused by Echinococcus granulosus.
  • Basophils play a crucial role in allergic reactions and immune responses.
  • Understanding immune cell behavior in parasitic infections is vital for diagnosis and treatment.

Purpose of the Study:

  • To investigate the releasability of immunoglobulin E (IgE)-mediated and non-IgE-mediated pathways in basophils from hydatidosis patients.
  • To compare histamine release in response to IgE-dependent and non-IgE-dependent stimuli between patients and healthy individuals.

Main Methods:

  • Collected blood samples from 31 patients diagnosed with hydatidosis.
  • Isolated basophils and challenged them with anti-human IgE (for IgE-mediated release) and non-IgE-dependent stimuli.

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  • Measured histamine release from basophils using appropriate assays.

    • Main Results:

    • Histamine release to non-IgE-dependent stimuli showed no significant difference between hydatidosis patients and normal individuals.
    • Basophils from hydatidosis patients exhibited significantly increased histamine liberation when challenged with anti-human IgE.
    • This indicates an enhanced IgE-dependent pathway in basophils of infected individuals.

    Conclusions:

    • Echinococcus granulosus infection leads to heightened sensitivity of basophils to IgE-dependent stimuli.
    • The findings suggest a potential role for IgE-mediated mechanisms in the immune response to hydatidosis.
    • Further research may explore therapeutic strategies targeting this enhanced basophil sensitivity.