Related Experiment Video
Updated: Aug 6, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian
Sun Shim Choi1, Eric J Vallender, Bruce T Lahn
1Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, USA.
Abstract:
The 3-dimensional (3D) structural context of amino acid residues in a protein could significantly impact the level of selective constraint on the residues. Here, by analyzing 767 mammalian proteins, we systematically investigate how various 3D structural contexts influence selective constraint. The structural contexts we examined include solvent accessibility, secondary structure, and intramolecular residue-residue interactions. Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint.
More Related Videos
Related Concept Videos
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Organization
The primary structure of a protein is its amino acid sequence.
Evolutionary Relationships through Genome Comparisons
Conservation of Protein Domains
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme can...

