Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spinal cord stimulation.

Milan P Stojanovic1, Salahadin Abdi

  • 1Interventional Pain Program, MGH Pain Center, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Cambridge, MA 02135, USA.

Pain Physician
|August 12, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Updated 2026 Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.

Pain physician·2026
Same author

Leveraging artificial intelligence to optimize neuromodulation in the treatment of patients with chronic pain.

Frontiers in pain research (Lausanne, Switzerland)·2026
Same author

Risk Factors of Chemotherapy-Induced Painful Peripheral Neuropathy: A Retrospective Study from A Single Cancer Center.

Pain physician·2026
Same authorSame journal

In Response to Comment on "Diagnostic Guidance for Chronic Complex Regional Pain Syndrome Type I and Type II from The American Society of Interventional Physicians (ASIPP)".

Pain physician·2026
Same author

Synaptic Plasticity as a Mechanism of Opioid Tolerance and Hyperalgesia.

Biology·2026
Same author

Gait as a quantitative indicator of the severity of chemotherapy-induced peripheral neuropathy: a pilot study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same journal

An Updated (2026) Best-Evidence Synthesis Appraisal of the Diagnostic Accuracy and Utility of Facet (Zygapophysial) Joint Injections in Chronic Spinal Pain.

Pain physician·2026
Same journal

In Errata.

Pain physician·2026
Same journal

In Response to Comment on "BMJ Publications on Interventional Techniques Do Not Meet Appropriateness Criteria of Conducting a Rapid Review: A Comprehensive Review".

Pain physician·2026
Same journal

Comment on "BMJ Publications on Interventional Techniques Do Not Meet Appropriateness Criteria of Conducting a Rapid Review: A Comprehensive Review".

Pain physician·2026
See all related articles

Spinal cord stimulation (SCS) effectively manages chronic low back pain by modulating nerve activity. This minimally invasive neuromodulation technique offers significant pain relief and functional improvement for many patients.

Area of Science:

  • Neuromodulation
  • Pain Management
  • Neuroscience

Background:

  • Spinal cord stimulation (SCS) is a primary neuromodulation therapy for chronic low back pain.
  • Its mechanism is rooted in the gate control theory and involves inhibiting dorsal horn neuronal activity.
  • Additional mechanisms include effects on allodynia, GABAergic action, ischemia, and brain activity.

Purpose of the Study:

  • To review the pathophysiology, mechanism of action, and indications for spinal cord stimulation.
  • To discuss the clinical effectiveness and controversial aspects of SCS in pain management.
  • To provide a comprehensive overview of SCS for neuropathic pain.

Main Methods:

  • Literature review of studies on spinal cord stimulation.
  • Analysis of the gate control theory and other proposed mechanisms of action.

Related Experiment Videos

  • Examination of clinical trial data on SCS efficacy and patient outcomes.
  • Main Results:

    • Spinal cord stimulation is indicated for conditions like failed back surgery syndrome and complex regional pain syndrome.
    • Clinical studies show a 50-70% success rate for SCS in treating low back and lower extremity neuropathic pain.
    • Patients experience decreased pain intensity, improved function, and reduced medication use.

    Conclusions:

    • Spinal cord stimulation is a proven, minimally invasive treatment for chronic neuropathic pain.
    • Evidence supports its efficacy in improving patient function and quality of life.
    • Further discussion on SCS techniques and controversial aspects is warranted.