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Clinical response is associated with elevated plasma interleukin-1 receptor antagonist during selective granulocyte

Kyoya Sakimura1, Toshihide Omori, Etsuro Iwashita

  • 1Department of Internal Medicine, Saitama Red Cross Hospital, Saitama, Japan.

Digestive Diseases and Sciences
|August 12, 2006
PubMed

Depletion of granulocytes and monocytes (GM) by selective apheresis (GMA) with an Adacolumn exerts an anti-inflammatory effect in patients with ulcerative colitis (UC) or rheumatoid arthritis. However, the mechanism of the anti-inflammatory effect of GMA is not fully understood yet. We investigated the effect of GMA on the plasma concentration of interleukin-1 receptor antagonist (IL-1ra), a potent anti-inflammatory cytokine. Twenty-six patients with active UC received GMA at one session per week for 5 consecutive weeks. Clinical response was defined as Deltaclinical activity index (DeltaCAI=CAI at entry - CAI at post)>or=4, while clinical remission was defined as CAI

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