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Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
Bacillisporins D and E, new oxyphenalenone dimers from Talaromyces bacillisporus
Tida Dethoup1, Leka Manoch, Anake Kijjoa
1Department of Plant Pathology, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand.
Abstract:
The oligophenalenone dimer duclauxin and two new analogues, bacillisporins D and E, were isolated from the fungus TALAROMYCES BACILLISPORUS in addition to the previously reported bacillisporins A, B and C. Structures were established by spectroscopic studies. Duclauxin and bacillisporins A, B, C and E were evaluated for cytotoxicity against three human cancer cell lines. Bacillisporin A was strongly active against MCF-7 and NCI-H460 and moderately active against SF-268 while bacillisporins B, C and duclauxin were moderately active against all three cell lines.
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