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Related Experiment Videos

A mouse strain difference in tumorigenesis induced by biodegradable polymers.

Saifuddin Ahmed1, Toshie Tsuchiya

  • 1Division of Medical Devices, National Institute of Health Sciences, 1-18-1 Kamiyoga, Tokyo 158-8501, Japan.

Journal of Biomedical Materials Research. Part A
|August 12, 2006
PubMed
Summary

Poly-L-lactic acid (PLLA) bone implants can affect subcutaneous tissue, increasing tumor risk in susceptible mice. Further research is needed to understand these PLLA effects on tumorigenicity.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Oncology

Background:

  • Poly-L-lactic acid (PLLA) is increasingly used for bone fracture repair implants.
  • The in vivo biological effects of PLLA implants on host tissues require further investigation.
  • Mouse strain differences in tumorigenicity may influence the host response to PLLA.

Purpose of the Study:

  • To evaluate the in vivo effects of PLLA plates on subcutaneous tissue in two mouse strains with differing tumorigenicity (BALB/cJ and SJL/J).
  • To assess the impact of PLLA implantation on cellular communication, protein expression, and tumor formation.
  • To correlate PLLA-induced tissue changes with tumorigenic potential.

Main Methods:

  • PLLA plates were implanted subcutaneously into BALB/cJ (high tumorigenicity) and SJL/J (low tumorigenicity) mice.

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  • Analysis included gap-junctional intercellular communication, connexin 43 protein expression, and secretion/expression of specific growth factors and matrix proteins.
  • Cells from PLLA-implanted mice were cultured and implanted into nude mice to assess tumorigenicity.

    • Main Results:

    • PLLA implantation in BALB/cJ mice significantly suppressed gap-junctional communication and connexin 43 expression.
    • PLLA-implanted BALB/cJ mice showed increased transforming growth factor-beta1, extracellular matrix, IGFBP3, and CRIP2.
    • Tumors formed in nude mice after implantation of cells from PLLA-treated BALB/cJ mice, but not from SJL/J mice.

    Conclusions:

    • PLLA implants induce significant molecular and cellular changes in subcutaneous tissue, particularly in a high-tumorigenicity mouse model.
    • These PLLA-induced changes are associated with an increased potential for tumor formation.
    • The findings highlight the importance of considering host tumorigenicity when evaluating the long-term biological effects of PLLA biomaterials.