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A convenient synthesis of an anti-Helicobacter pylori agent, dehydrodiconiferyl alcohol
1College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea.
Abstract:
Potential anti-Helicobacter pylori agent dehydrodiconiferyl alcohol was synthesized in 44% overall yield, starting from vanillin which could be commercially available. Carbon extension of vanillin followed by the Horner-Wadsworth-Emmons reaction, a biomolecular radical coupling reaction and DIBAL-H reduction gave dehydrodiconiferyl alcohol.
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