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Gerstmann-Sträussler-Scheinker disease. II. An effect of GSS mutation on PRP structure

Paweł P Liberski1, Mariusz Jaskólski, Paul Brown

  • 1Department of Molecular Pathology and Neuropathology, Medical University of Lódź, Poland.

Folia Neuropathologica
|August 15, 2006
PubMed
Abstract

No abstract available in PubMed .

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Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...