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HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial
P Hafkemeyer1, K A Neftel, U Hübscher
1Institute of Pharmacology and Biochemistry, University Zürich-Irchel, Switzerland.
Methods and Findings in Experimental and Clinical Pharmacology
|January 1, 1990
Abstract:
Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.