Related Experiment Video
Updated: Aug 6, 2026

Rapid Encapsulation of Reconstituted Cytoskeleton Inside Giant Unilamellar Vesicles
Published on: November 10, 2021
Jørgensen complex within a molecular container: selective encapsulation of trans-[Co(en)2Cl2]+ into cucurbit[8]uril
Tatiana V Mitkina1, Maxim N Sokolov, Dmitry Y Naumov
1Nikolaev Institute of Inorganic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentiev Avenue 3, Novosibirsk 630090, Russian Federation.
Abstract:
The unprecedented selective encapsulation of trans-[Co(en)2Cl2]+ from the mixture of trans and cis isomers into the cavity of macrocyclic cavitand cucurbit[8]uril (C48H48N32O16, CB[8]) leads to the inclusion compound {trans-[Co(en)2Cl2]@CB[8]}Cl.17H2O (1). Single-crystal X-ray analysis, 1H NMR, and ESI-MS spectra confirm the formation of host-guest complex 1 in both solid state and solution. The geometry of the complex cation alters significantly upon inclusion, which causes appreciable hypsochromic shifts of the absorption bands of the guest complex. According to TGA data, inclusion of trans-[Co(en)2Cl2]+ dramatically stabilizes the complex toward thermal decomposition. Encapsulation of trans-[Co(en)2Cl2]+ into the CB[8] cavity also increases the stability of the metal complex toward isomerization into the cis form. The supramolecular adduct {cis-[Co(en)2(H2O)2](CB[8])6}Cl3.ca109.5H2O (2) was isolated only after prolonged heating of an aqueous solution of 1 at 120 degrees C in an evacuated tube; it was characterized by X-ray crystallography, IR, and elemental analysis.
More Related Videos
10:02Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
Published on: October 3, 2020
07:14Reconstitution of the Bacterial Glutamate Receptor Channel by Encapsulation of a Cell-Free Expression System
Published on: March 8, 2024
Related Concept Videos
Complexation Equilibria: The Chelate Effect
Complexation Equilibria: Overview
The equilibrium constant of the complexation reaction is represented as the formation constant...
Crystal Field Theory - Octahedral Complexes
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
Complexation Equilibria: Factors Influencing Stability of Complexes
Vesicular Tubular Clusters
With the help of motor proteins such...
Formation of Complex Ions