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Updated: Aug 6, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Plasma lipid concentrations after 1.5 years of exposure to nevirapine or efavirenz together with stavudine and
F van Leth1, D B Hall, J M A Lange
1International Antiviral Therapy Evaluation Center, Amsterdam, the Netherlands. vanlethf@kncvtbc.nl
Objectives:
To assess long-term changes in lipids and lipoproteins concentrations associated with exposure to non-nucleoside reverse transcriptase inhibitors.
Methods:
Long-term analysis of plasma lipid concentrations was performed in patients starting first-line antiretroviral therapy with stavudine (d4T) and lamivudine, and either nevirapine or efavirenz.
Results:
Concentrations of total cholesterol, low-density lipoprotein cholesterol and triglycerides continued to increase, while high-density lipoprotein cholesterol showed a slight decrease compared with earlier reported increases after 48 weeks.
Conclusions:
Changes in body fat distribution expected to occur with continued exposure to d4T could offer a potential explanation for these findings.
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