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Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple

Daniel A Pollard1, Alan M Moses, Venky N Iyer

  • 1Graduate Group in Biophysics, University of California, Berkeley, CA 94720, USA. dpollard@berkeley.edu

BMC Bioinformatics
|August 15, 2006
PubMed
Summary

Multiple alignment accuracy in molecular evolution is mainly driven by the divergence between the two most distant species. This impacts inferences of transcription factor binding site conservation and divergence estimates, particularly on internal tree branches.

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