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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

Multiple resistance mechanisms to azole antifungals in yeast clinical isolates

D Sanglard1, F Ischer, D Calabrese

  • 1Institut de Microbiologie, Centre Hospitulier Universitaire Vaudois, Lausanne, Switzerland. dsanglar@eliot.unil.ch

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|August 15, 2006
PubMed

Insights

Antifungal azole resistance is rising in Candida species due to increased use of these drugs. Understanding molecular mechanisms is key to developing new treatments and strategies against fungal infections.

Area of Science:

  • Medical Mycology
  • Molecular Biology
  • Antimicrobial Resistance

Background:

  • Increased incidence of fungal infections, especially in immunocompromised patients.
  • Widespread use of azole antifungals has led to rising resistance.
  • Candida species, including C. albicans and C. glabrata, are significant pathogens exhibiting acquired resistance.

Purpose of the Study:

  • To review the latest research on molecular mechanisms of azole resistance in Candida species.
  • To highlight the significance of understanding these mechanisms for future therapeutic strategies.

Main Methods:

  • Literature review of recent investigations into azole resistance mechanisms.
  • Analysis of molecular pathways and genetic factors contributing to resistance.

Main Results:

  • Multiple resistance mechanisms have been identified in azole-resistant Candida isolates.
  • These mechanisms can be present concurrently in clinical isolates, complicating treatment.
  • Key molecular targets and pathways involved in azole resistance have been elucidated.

Conclusions:

  • Understanding azole resistance mechanisms is crucial for developing novel antifungal agents.
  • Strategies to overcome or delay the emergence of resistance are needed.
  • Further research into the molecular basis of resistance will inform clinical practice and drug development.

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