Related Experiment Video
Updated: Jan 20, 2026
Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
Changes in bleeding patterns with depot medroxyprogesterone acetate subcutaneous injection 104 mg
Raquel D Arias1, John K Jain, Cosima Brucker
1Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. rarias@hsc.usc.edu
Objective:
This study aims to assess changes in bleeding patterns with the use of depot medroxyprogesterone acetate (DMPA) 104 mg/0.65 ml subcutaneous injection (DMPA-SC 104).
Study Design:
An analysis was conducted using data from two 1-year, noncomparative clinical trials (N=1787) and a 2-year randomized study comparing DMPA-SC 104 (N=266) with DMPA intramuscular injection (DMPA-IM). Bleeding was analyzed per 30-day interval by category and number of days. Analyses also were performed for age and body mass index (BMI) subgroups and for the percentages of women shifting from bleeding/spotting to amenorrhea after each injection.
Results:
Each study showed decreased incidence of irregular bleeding and increased amenorrhea with continued use of DMPA-SC 104. Rates of amenorrhea at Month 12 (52-64% across studies) and Month 24 (71% in the 2-year trial) were comparable with those originally reported for DMPA-IM. Changes in bleeding patterns showed no consistent differences according to age or BMI. The percentages of subjects shifting from bleeding and/or spotting to amenorrhea increased with each subsequent injection.
Conclusion:
Clinical data show that the incidence of amenorrhea increases over time with the use of DMPA-SC 104.
Related Concept Videos
09:00Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
06:31Identification and Dissection of Diverse Mouse Adipose Depots
08:53Localization, Identification, and Excision of Murine Adipose Depots
03:52Subcutaneous Injection of Bacterial Antigen to Induce Systemic Inflammation in a Murine Model
01:22Bleeding in Fresh Concrete
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
01:24Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...