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Updated: Aug 6, 2026

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
Myocardial scars more frequent than expected: magnetic resonance imaging detects potential risk group
Charlotte Ebeling Barbier1, Tomas Bjerner, Lars Johansson
1Department of Radiology, Uppsala University Hospital, Uppsala, Sweden.
Objectives:
The aim of this study was to investigate the prevalence of clinically recognized myocardial infarctions (RMIs) and unrecognized myocardial infarctions (UMIs) in 70-year-old subjects, assessed with magnetic resonance imaging (MRI), and to relate the findings to cardiac function and morbidity.
Background:
Late enhancement MRI identifies myocardial scars and thereby has the potential to detect UMI.
Methods:
Cardiac MRI was performed on 259 randomly chosen 70-year-old subjects. Late enhancement and cine sequences were acquired, and the ejection fraction and left ventricular (LV) mass were calculated. Late enhancement involving the subendocardial layer was considered to represent myocardial infarction (MI) scars, and their volumes were calculated. Information on cardiac morbidity and risk factors was collected from medical records and from a health examination. Subjects with MI scars, with or without a hospital diagnosis of MI were classified as RMI or UMI, respectively.
Results:
The images from 248 subjects (123 women, 125 men) were assessable. Myocardial infarction scars were found in 60 subjects (24.2%), in 49 of whom (19.8%) they were UMIs. The volumes of the UMIs were significantly smaller than those of the RMIs. There was an increased frequency of chest pain symptoms among the subjects with UMI or RMI compared with those without MI scars. Ejection fraction was significantly lower and LV mass significantly larger in the subjects with UMI or RMI than in those without MI scars.
Conclusions:
Unrecognized MI detected with MRI was more frequent than expected in 70-year-old subjects. The subjects displaying these UMIs may represent a previously unknown potential risk group for future cardiovascular events.
Insights
Unrecognized myocardial infarctions (UMIs) were common in 70-year-olds, detected by MRI. These individuals may face increased cardiovascular risk, highlighting a previously unknown risk group.
Area of Science:
- Cardiology
- Radiology
- Geriatrics
Background:
- Late enhancement magnetic resonance imaging (MRI) can identify myocardial scars, aiding in the detection of unrecognized myocardial infarctions (UMIs).
- Assessing myocardial infarction (MI) prevalence in older adults is crucial for understanding cardiovascular disease burden.
Purpose of the Study:
- To determine the prevalence of recognized (RMIs) and unrecognized myocardial infarctions (UMIs) in 70-year-olds using cardiac MRI.
- To correlate MI findings with cardiac function (ejection fraction, LV mass) and morbidity.
Main Methods:
- Cardiac MRI, including late enhancement and cine sequences, was performed on 259 randomly selected 70-year-old subjects.
- Ejection fraction and left ventricular (LV) mass were calculated; MI scars were identified by subendocardial late enhancement.
- Subjects were classified as RMI or UMI based on MI scars and hospital diagnosis records.
Main Results:
- Myocardial infarction scars were detected in 24.2% of subjects, with UMIs accounting for 19.8%.
- UMIs were significantly smaller than RMIs.
- Subjects with MI scars (RMI or UMI) showed lower ejection fraction, larger LV mass, and increased chest pain symptoms compared to those without MI scars.
Conclusions:
- Unrecognized myocardial infarction (UMI) is more prevalent than anticipated in 70-year-old individuals.
- Individuals with UMIs identified by MRI may constitute a previously unrecognized risk group for future cardiovascular events.
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