Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exogenous pro-angiogenic stimuli cannot prevent physiologic vessel regression.

Ankush Gosain1, Annette M Matthies, Julia V Dovi

  • 1Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Burn and Shock Trauma Institute, Maywood, Illinois, USA.

The Journal of Surgical Research
|August 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal changes in gene regulation during human tissue repair.

Scientific reports·2026
Same author

The power of parts and the strength of the whole: Aggregation, disaggregation, and a strategic vision for the society of Asian academic surgeons.

American journal of surgery·2026
Same author

A role for ETV1 and endothelial cell-derived extracellular vesicle microRNAs in priming fibroblast response to vesicle-bound FGF2.

bioRxiv : the preprint server for biology·2026
Same author

Implementation and Effectiveness of an Enhanced Recovery Protocol for Children Undergoing Surgery: The ENRICH-US Stepped-Wedge Cluster-Randomized Trial.

JAMA surgery·2026
Same author

Spatio-temporal multiscale cell modeling of skin wound healing.

Biophysical journal·2026
Same author

Response of Oral and Skin Keratinocytes to Oxidative Stress.

Cells·2026

Maintaining pro-angiogenic stimuli like vascular endothelial growth factor (VEGF) did not prevent blood vessel regression in healing wounds. Anti-angiogenic signals appear dominant, suggesting new therapeutic targets for wound healing.

Area of Science:

  • Wound healing research
  • Angiogenesis and vascular biology
  • Biomedical engineering

Background:

  • Wound healing involves angiogenesis, driven by vascular endothelial growth factor (VEGF).
  • Pro-angiogenic factors decrease before vessel regression in wounds.
  • This suggests these factors are crucial for maintaining vessel density.

Purpose of the Study:

  • To investigate if sustained pro-angiogenic stimuli can prevent physiological vessel regression in wounds.
  • To explore the role of exogenous growth factors in modulating wound angiogenesis.

Main Methods:

  • A modified sponge wound model utilizing mini-osmotic pumps for growth factor delivery.
  • Exogenous vascular endothelial growth factor (VEGF), FGF, or PDGF were administered.

Related Experiment Videos

  • Blood vessel density was quantified using immunohistochemistry.

    • Main Results:

    • VEGF administration led to a temporary increase in wound vessel density.
    • None of the tested pro-angiogenic factors (VEGF, FGF, PDGF) prevented vascular regression.
    • Statistical analysis showed no significant effect (P = NS) on preventing regression.

    Conclusions:

    • Anti-angiogenic signals strongly override pro-angiogenic stimuli in later wound healing stages.
    • Therapeutic strategies may require targeting anti-angiogenic pathways to modulate vessel density.
    • Further research into manipulating anti-angiogenic signals is warranted for clinical applications.