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Benign prostatic hyperplasia and growth factors.

R K Lawson1

  • 1Department of Urology, Medical College of Wisconsin, Milwaukee.

Der Urologe. Ausg. A
|January 1, 1990
PubMed
Summary

Benign prostatic hyperplasia (BPH) may be caused by growth factors. Basic fibroblast growth factor (bFGF) is present in BPH and synthesized by prostate fibroblasts, suggesting a role in stromal and epithelial growth.

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Area of Science:

  • Urology
  • Cell Biology
  • Molecular Biology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Previous research suggests BPH originates as a stromal disease, with hyperplastic stroma stimulating epithelial cell growth.
  • Quantitative data support BPH being primarily a stromal disease.

Purpose of the Study:

  • To investigate the role of growth factors in the etiology of benign prostatic hyperplasia (BPH).
  • To determine if basic fibroblast growth factor (bFGF) is involved in human BPH.
  • To formulate hypotheses regarding growth factor involvement in prostate hyperplasia.

Main Methods:

  • Review of morphological and quantitative morphometric data.
  • Analysis of experimental embryology findings related to growth factors.
  • Laboratory investigation of growth factors in human BPH tissue.

Main Results:

  • Basic fibroblast growth factor (bFGF) is identified as a primary growth factor in human BPH.
  • bFGF is synthesized by prostate fibroblasts.
  • bFGF concentrations may be elevated in the periurethral tissues affected by BPH.

Conclusions:

  • Circumstantial evidence suggests growth factors, particularly bFGF, play a role in BPH development.
  • Further research is needed to establish a definitive link between growth factors and hyperplastic prostate growth.
  • Hypotheses are proposed to guide future investigations into growth factors and BPH.

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