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A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality
Jiang-Fei Wang1, Dong Zhang, Ji-Zong Zhao
1Department of Neurosurgery, Beijing TianTan Hospital, Capital University of Medical Sciences, Beijing 100050, China. wjf1998@yeah.net
Background:
To investigate the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality.
Methods:
We compared the occurrence of HLA-DR and HLA-DQ antigens in patients with intracranial saccular aneurysm and in the control group by PCR and agarose gel electrophoresis.
Results:
No statistically significant correlation between HLA-DR, HLA-DQ antigen frequency, and the pathogenesis and clinical characteristics of intracranial aneurysm has been found.
Conclusions:
We have not found any relationship between HLA-DR and HLA-DQ antigen frequency, haplotype frequency, and pathogenesis and clinical characteristics of intracranial aneurysm, but the patients who presented with HLA-DR53, DR52, DQ7(3), and DQ5(1) seem to be more likely to bear multiple intracranial aneurysms.