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Ganoderma - a therapeutic fungal biofactory.
1Micoteca da Universidade do Minho, Centro de Engenharia Biológica, Campus de Gualtar, 4710-057 Braga, Portugal. russell.paterson@deb.uminho.pt
Phytochemistry
|August 15, 2006
Summary
This review explores the medicinal fungus Ganoderma, also known as Lingzhi or Reishi. It highlights its traditional uses and scientifically validated biological activities, including anti-cancer properties, for modern therapeutic applications.
Area of Science:
- Mycology
- Pharmacology
- Ethnobotany
Background:
- Ganoderma, a white rot fungus, has a long history of medicinal use in East Asia.
- Commonly known as Lingzhi, Reishi, and other names, its preparations are widely recognized.
- Extensive research has focused on Ganoderma lucidum, exploring its therapeutic potential.
Purpose of the Study:
- To review and collate publications on the biological activities and compounds of Ganoderma species.
- To evaluate the most scientifically valid claims of effectiveness for Ganoderma preparations.
- To emphasize the biological activities distinct from structure/activity relationships.
Main Methods:
- Literature review of scientific publications on Ganoderma.
- Analysis of reported biological activities and chemical constituents (polysaccharides, terpenoids).
- Assessment of scientific rigor and evidence for claimed therapeutic effects.
Main Results:
- Ganoderma exhibits a wide range of biological activities relevant to major diseases.
- Reported effects span from anti-cancer to alleviating bladder issues.
- Convincing scientific evidence is primarily associated with assays of pure compounds.
Conclusions:
- Ganoderma represents an ancient remedy with significant relevance to modern medicine.
- Further research is needed to validate therapeutic effects and develop effective medicines.
- Challenges in mass production may hinder the development of Ganoderma-based pharmaceuticals.