Related Experiment Video
Updated: Aug 6, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Postnatal factors associated with failure to thrive in term infants in the Avon Longitudinal Study of Parents and
1Centre for Child and Adolescent Health, Department of Community-Based Medicine, University of Bristol, Bristol, UK. alan.emond@bristol.ac.uk
Insights
Postnatal feeding efficiency and infant sucking problems significantly impact infant growth faltering. These factors are more influential than social class or parental education for healthy infant development.
Area of Science:
- Pediatrics
- Infant Nutrition
- Growth and Development
Background:
- Failure to thrive (FTT) in infancy is a significant concern.
- Understanding postnatal influences is crucial for early intervention.
- Previous research has explored various risk factors for FTT.
Purpose of the Study:
- To investigate the contribution of postnatal factors to infant failure to thrive.
- To identify key feeding-related and other postnatal influences on infant growth faltering.
Main Methods:
- Utilized data from 11,900 infants in the Avon Longitudinal Study of Parents and Children (ALSPAC).
- Calculated conditional weight gain from birth to 8 weeks and 8 weeks to 9 months.
- Defined growth faltering as conditional weight gain below the 5th centile.
Main Results:
- Identified 528 cases of growth faltering (birth to 8 weeks) and 495 cases (8 weeks to 9 months).
- Maternal height <160 cm and age >32 years predicted poor infant growth.
- Infant sucking problems and illness were associated with early growth faltering; feeding efficiency and weaning were key later on.
Conclusions:
- Feeding type and efficiency are the most critical postnatal factors for growth faltering.
- Weak sucking is a primary indicator in early infancy for both breastfed and bottle-fed infants.
- Post-8 weeks, breastfeeding duration, milk intake, and weaning success are paramount.
Objective:
To assess the contribution of postnatal factors to failure to thrive in infancy.
Methods:
11 900 infants from the Avon Longitudinal Study of Parents and Children (ALSPAC), born at 37-41 weeks' gestation, without major malformations and with a complete set of weight measurements in infancy (83% of the original ALSPAC birth cohort) were studied. Conditional weight gain was calculated for the periods from birth to 8 weeks and 8 weeks to 9 months. Cases of growth faltering were defined as those infants with a conditional weight gain below the 5th centile.
Results:
Analysis yielded 528 cases of growth faltering from birth to 8 weeks and 495 cases from 8 weeks to 9 months. In multivariable analysis, maternal factors predicting poor infant growth were height <160 cm and age >32 years. Growth faltering between birth and 8 weeks was associated with infant sucking problems regardless of the type of milk, and with infant illness. After 8 weeks of age, the most important postnatal influences on growth were the efficiency of feeding, the ability to successfully take solids and the duration of breast feeding.
Conclusions:
The most important postnatal factors associated with growth faltering are the type and efficiency of feeding: no associations were found with social class or parental education. In the first 8 weeks of life, weak sucking is the most important symptom for both breastfed and bottle-fed babies. After 8 weeks, the duration of breast feeding, the quantity of milk taken and difficulties in weaning are the most important influences.
More Related Videos
Related Concept Videos
Teratogenicity
Attachment
Development of Human Microbiota
Development of the Oral Microbiota
Nature and Nurture
Longitudinal Research

