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Related Experiment Videos

Radiation-induced xerostomia.

Mark S Chambers1, David I Rosenthal, Randal S Weber

  • 1Department of Head and Neck Surgery, The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA. mchamber@mdanderson.org

Head & Neck
|August 15, 2006
PubMed
Summary
This summary is machine-generated.

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Radiation therapy for head and neck cancer can cause dry mouth (xerostomia). Recent advancements offer improved prevention and treatment strategies for this common side effect.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Oral Medicine

Background:

  • Radiation-induced xerostomia is a common and often permanent side effect of head and neck cancer radiation therapy.
  • This condition significantly impacts patients' quality of life.

Purpose of the Study:

  • To review recent developments in the prevention and treatment of radiation-induced xerostomia.
  • To identify effective strategies for managing this side effect.

Main Methods:

  • A literature search of the Medline database was conducted for articles published in the last 10 years.
  • Proceedings from national meetings and clinical trial registries were also consulted.
  • Priority was given to randomized controlled trials, with inclusion of small open trials due to scarcity.

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Main Results:

  • Preventive approaches include conformal radiation delivery, radioprotective agents, and preirradiation surgical techniques.
  • Therapeutic interventions involve supportive care, saliva supplementation, and pro-cholinergic salivary secretagogues.

Conclusions:

  • Radiation-induced xerostomia is a significant morbidity following orofacial irradiation.
  • A combination of careful preventive techniques, supportive care, and new agents may be beneficial.