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Updated: Jul 23, 2026

In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
Down-regulated VEGF expression in the diabetic heart is normalized by an endothelin ETA receptor antagonist
Subrina Jesmin1, Takashi Miyauchi, Katsutoshi Goto
1Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Abstract:
Recently, down-regulation of vascular endothelial growth factor (VEGF) in the heart was suggested as a potential molecular explanation for the increased risk of cardiovascular morbidity and mortality in patients with diabetes. Increased endothelin-1 production is reported in diabetes. Here, we report that down-regulated VEGF expression in the diabetic rat heart is normalized by an endothelin ETA receptor antagonist, suggesting that endothelin antagonism may be a novel therapeutic strategy for diabetic heart.
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