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Cell aggregation: packing soft grains.

J A Aström1, M Karttunen

  • 1Centre for Scientific Computing, P.O. Box 405 FIN-02101 Esbo, Finland.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|August 16, 2006
PubMed
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Cellular aggregates control solvent diffusion. Cell adhesion mechanisms and packing frustration critically influence intercellular spacing and void channels, impacting diffusion, even under high pressure.

Area of Science:

  • Biophysics
  • Materials Science
  • Physical Chemistry

Background:

  • Cellular aggregates are collections of membrane-enclosed units with internal and external pressure differences.
  • Cell cohesion is maintained by membrane adhesion and/or confined space compression.
  • Intercellular spacing in cellular aggregates influences solvent diffusion.

Purpose of the Study:

  • To investigate cellular packing in confined spaces using a physical approach.
  • To understand the role of cell wall adhesion in forming intercellular void channels.
  • To determine how packing frustration affects solvent diffusion in cellular aggregates.

Main Methods:

  • A physical approach was employed to study cellular packings.
  • Average material properties were derived from free energy calculations.

Related Experiment Videos

  • The influence of cell wall adhesion on aggregate formation and diffusion was analyzed.

    • Main Results:

    • The formation of penetrating intercellular void channels is critically dependent on cell wall adhesion mechanisms during aggregate formation.
    • A fully relaxed aggregate effectively impedes solvent diffusion at high hydrostatic pressures.
    • A small degree of adhesion-related packing frustration (around 0.1) can disrupt diffusion blockage even under high pressure.

    Conclusions:

    • Cell adhesion and packing frustration are key factors governing solvent diffusion in cellular aggregates.
    • Understanding these mechanisms is crucial for controlling transport properties in biological and engineered systems.
    • The study provides insights into the physical principles underlying cellular aggregate behavior and their implications for diffusion processes.