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Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
Published on: September 16, 2020
Boundary-induced spatiotemporal complex patterns in excitable systems
Olga Nekhamkina1, Moshe Sheintuch
1Department of Chemical Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel.
Abstract:
We show that inhomogeneous boundary conditions (BCs) in a distributed reaction-diffusion excitable system are a natural source of permanent perturbations that can induce wave trains, which can be characterized as mixed-mode temporal oscillations and, when a parameter is varied, admit a period-adding bifurcation. To that end we analyze: a pair of coupled excitable and oscillatory cells, a distributed FitzHugh-Nagumo model, and a distributed five-variable model that describes catalytic oxidation. The obtained results account for the recently reported experimental observations of mixed-mode oscillations showing a period-adding bifurcation during oxidation on a disk-shaped catalytic cloth with imposed cold temperature BC.
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