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Related Experiment Videos

Rethinking contact lens associated keratitis.

Nathan Efron1, Philip B Morgan

  • 1School of Optometry, Queensland University of Technology, Brisbane, Australia. n.efron@qut.edu.au

Clinical & Experimental Optometry
|August 16, 2006
PubMed
Summary
This summary is machine-generated.

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Contact lens wear can cause corneal infiltrative events (CIEs), which are best viewed as a disease spectrum. Immediate lens removal and antimicrobial therapy are crucial for sore eyes with CIEs to prevent vision loss.

Area of Science:

  • Ophthalmology
  • Contact Lens Technology
  • Epidemiology

Background:

  • Contact lens wear is associated with corneal infiltrative events (CIEs).
  • Current classification schemes for CIEs have limitations.
  • Understanding CIE epidemiology is crucial for patient care.

Purpose of the Study:

  • To critically analyze binomial and polynomial classification schemes for CIEs.
  • To investigate the epidemiology of CIEs in contact lens wearers.
  • To challenge traditional thinking on contact lens-associated keratitis.

Main Methods:

  • Review of existing literature on CIE classification and epidemiology.
  • Analysis of data from the Manchester Keratitis Study (12-month prospective study).
  • Utilized a novel clinical severity matrix, Venn diagrams, cartographic analysis, and logistic analysis.

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Main Results:

  • Binomial schemes present ambiguities; polynomial schemes show significant overlap.
  • Corneal infiltrate location varies by lens type (silicone hydrogel extended wear, daily hydrogel disposables, daily hydrogel non-disposables).
  • Overnight wear, conventional hydrogel extended wear, male gender, smoking, and winter months increase CIE risk; limbal infiltrates are less severe.

Conclusions:

  • CIEs represent a continuous spectrum of ocular disease, not discrete categories.
  • Immediate contact lens removal and antimicrobial therapy are recommended for worsening sore eyes with observed CIEs.
  • The rate of significant visual loss from CIEs is low, but prompt management is essential.