Related Experiment Video
Updated: Aug 6, 2026
05:37
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
IL-1RN gene polymorphism is associated with peri-implantitis
Marja L Laine1, Asa Leonhardt, Ann-Marie Roos-Jansåker
1Department of Oral Microbiology, ACTA Amsterdam, Amsterdam, The Netherlands.
Clinical Oral Implants Research
|August 16, 2006
Summary
Interleukin-1 receptor antagonist (IL-1RN) gene polymorphism is linked to peri-implantitis. This genetic variation may increase the risk of developing this inflammatory condition around dental implants.
Area of Science:
- Oral biology and immunology
- Periodontology and implant dentistry
- Genetics and molecular biology
Background:
- Interleukin-1 (IL-1) family cytokines and their antagonist (IL-1ra) are crucial in regulating periodontal inflammation.
- Genetic variations within the IL-1 gene cluster are associated with severe adult periodontitis.
- Peri-implantitis shares inflammatory pathways with periodontitis, suggesting a potential genetic link.
Purpose of the Study:
- To investigate the association between IL-1 gene cluster polymorphisms and peri-implantitis.
- To determine if specific IL-1 gene polymorphisms act as risk factors for peri-implantitis.
Main Methods:
- Genotyping of IL-1A, IL-1B, and IL-1RN gene polymorphisms using PCR from mouthwash samples.
- Study included 71 patients with peri-implantitis and 49 healthy controls.
- Analysis included logistic regression accounting for smoking, gender, and age.
Main Results:
- A significant difference in the carriage rate of IL-1RN gene allele 2 was observed between peri-implantitis patients (56.5%) and controls (33.3%).
- Carriage of IL-1RN allele 2 was independently associated with an increased risk of peri-implantitis (OR 3; P=0.02), even after adjusting for confounders.
- No significant differences were found for other investigated IL-1 gene polymorphisms.
Conclusions:
- The IL-1RN gene polymorphism is significantly associated with peri-implantitis.
- IL-1RN gene polymorphism may serve as a genetic risk factor for the development of peri-implantitis.
Related Concept Videos
03:18Non-LTR Retrotransposons
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
02:30Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
02:57piRNA - Piwi-interacting RNAs
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...