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Related Experiment Videos

Osteosarcoma arising in the breast.

Norimasa Sando1, Kuniyuki Oka, Takuya Moriya

  • 1Surgery, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|August 16, 2006
PubMed
Summary

This case study details a rare instance of breast osteosarcoma in a 49-year-old woman. Despite initial benign diagnoses, the aggressive tumor led to mastectomy and ultimately, fatal pulmonary metastases.

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Osteosarcoma is a rare primary bone cancer, with extremely rare occurrences in the breast.
  • Previous breast biopsies in this patient were diagnosed as fibroadenoma and benign phyllodes tumor.

Purpose of the Study:

  • To report a rare case of primary breast osteosarcoma.
  • To highlight the diagnostic challenges and aggressive nature of this rare malignancy.

Main Methods:

  • Case report of a 49-year-old female patient.
  • Histopathological examination of mastectomy specimen.
  • Immunohistochemical analysis of tumor cells.

Main Results:

  • A large (12x9x8.5 cm) osteosarcoma with osteoblastic and chondroblastic features was diagnosed.

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  • Tumor cells showed pleomorphism, high mitotic activity, and invasion of skin, blood, and lymph vessels.
  • Immunohistochemistry revealed vimentin, osteopontin, VEGF, CD10, and alkaline phosphatase expression; keratin was negative.
  • Chemotherapy was ineffective, and the patient developed fatal pulmonary metastases within 9 months.

    • Conclusions:

    • Primary breast osteosarcoma is an exceptionally rare and aggressive tumor.
    • Distinguishing it from other breast malignancies requires thorough histopathological and immunohistochemical evaluation.
    • The prognosis remains poor, with a high propensity for distant metastasis.