Related Experiment Videos
Calculated bioavailable testosterone levels and depression in middle-aged men.
Roger S McIntyre1, Deborah Mancini, Beata S Eisfeld
1Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. roger.mcintyre@uhn.on.ca
Psychoneuroendocrinology
|August 16, 2006
Summary
Lower bioavailable testosterone (BT) levels are linked to depressive symptoms in middle-aged men. This study found reduced BT and total testosterone (TT) in depressed individuals, suggesting BT changes may be a vulnerability factor.
Area of Science:
- Endocrinology
- Psychiatry
- Men's Health
Background:
- The link between total testosterone (TT) and depressive symptoms is unclear.
- Physiologically active bioavailable testosterone (BT) role in depression needs investigation.
Purpose of the Study:
- To determine the relationship between bioavailable testosterone (BT) and depressive symptoms.
- Compare BT levels in middle-aged men with and without major depressive disorder (MDD).
Main Methods:
- Assessed calculated BT levels in middle-aged men (40-65 years).
- Compared two groups: untreated men with MDD (N=44) and matched non-depressed controls (N=50).
Main Results:
- Depressed men showed significantly lower mean BT and TT levels than controls.
- Biochemical hypogonadism (low BT or TT) was more prevalent in depressed men.
Conclusions:
- Lower bioavailable testosterone (BT) concentration may indicate vulnerability to depressive symptoms.
- BT levels are associated with major depressive disorder in middle-aged men.