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Phosphodiester modification by zinc metalated adenine polymer with carboxyl pendants

Yogita Gupta1, G N Mathur, Masood Parvez

  • 1Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.

Bioorganic & Medicinal Chemistry Letters
|August 16, 2006
PubMed

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Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
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DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
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Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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