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Nutritional outcomes following pediatric intestinal transplantation

R S Venick1, D G Farmer, D Saikali

  • 1Department of Pediatrics, UCLA Pediatric GI, The David Geffen School of Medicine, University of California-Los Angeles, PO Box 91752, Los Angeles, CA 90095, USA. Rvenick@mednet.ucla.edu

Transplantation Proceedings
|August 16, 2006
PubMed

Insights

Children undergoing small bowel transplant (SBT) showed improved growth and nutritional markers post-surgery. However, zinc deficiency was common, and significant catch-up growth was not observed.

Area of Science:

  • Pediatric Surgery
  • Transplant Medicine
  • Nutritional Science

Background:

  • Intestinal transplant (SBT) is a complex procedure with potential long-term nutritional implications for pediatric patients.
  • Understanding post-transplant nutritional status is crucial for optimizing outcomes in children receiving SBT.

Purpose of the Study:

  • To describe the long-term nutritional outcomes in children following small bowel transplantation (SBT).
  • To evaluate changes in anthropometric and biochemical nutritional parameters after SBT.

Main Methods:

  • Retrospective review of 19 pediatric patients who underwent SBT between 1991 and March 2005.
  • Analysis of weight, height, albumin, prealbumin, zinc (Zn), and essential fatty acid (EFA) levels pre- and post-SBT.

Main Results:

  • Patients showed improved weight and height Z scores at 1 year post-SBT, which stabilized by year 2.
  • All patients were successfully weaned from total parenteral nutrition to elemental formula.
  • Seventeen of 19 patients exhibited zinc deficiency, and four had essential fatty acid deficiency post-SBT.

Conclusions:

  • Successful SBT supports growth and maintains nutritional parameters but does not lead to significant catch-up growth.
  • Post-SBT zinc deficiency is prevalent and requires further investigation.
  • Essential fatty acid supplementation needs careful monitoring in children on elemental formulas post-SBT.
Abstract

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