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Impact of hepatitis C virus on renal transplantation: association with poor survival

S Pedroso1, L Martins, I Fonseca

  • 1Nephrology and Transplant Departments, Hospital Geral de Santo António, Largo Professor Abel Salazar, 4050-011 Porto, Portugal. sofiapedroso@sapo.pt

Transplantation Proceedings
|August 16, 2006
PubMed

Insights

Hepatitis C virus (HCV) infection significantly lowers patient and kidney transplant survival rates. HCV-positive recipients experienced more infectious deaths, highlighting the virus's detrimental impact on long-term outcomes.

Area of Science:

  • Nephrology
  • Virology
  • Transplantation Immunology

Background:

  • Conflicting data exists on hepatitis C virus (HCV) impact on renal transplant outcomes.
  • HCV infection is a significant global health concern, particularly in transplant populations.

Purpose of the Study:

  • To evaluate the long-term effects of HCV infection on patient and allograft survival in renal transplant recipients.
  • To compare outcomes between HCV-positive and HCV-negative kidney transplant patients.

Main Methods:

  • Retrospective study of renal transplant recipients from July 1983 to December 2004.
  • Comparison of HCV-positive (n=155) and HCV-negative (n=1044) groups.
  • Analysis of patient/donor characteristics, graft survival, patient survival, and causes of death.

Main Results:

  • HCV-positive recipients had longer dialysis times, more transfusions, and more prior transplants.
  • No difference in acute rejection rates between groups.
  • Significantly lower patient and graft survival in HCV-positive recipients.
  • Increased infectious cause mortality in HCV-positive patients.

Conclusions:

  • HCV infection negatively impacts renal allograft and patient prognosis.
  • HCV poses a significant risk for infectious complications post-transplant.
  • HCV screening and management are crucial for improving transplant outcomes.

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