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Updated: Aug 1, 2026
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
Published on: October 31, 2007
No induction versus anti-IL2R induction therapy in simultaneous kidney pancreas transplantation: a comparative
L E Becker1, V A Nogueira, H Abensur
1Beneficencia Portuguesa Hospital and Albert Einstein Hospital, Rua Maestro Cardim 769, Bloco IV 01323-001 São Paulo, SP, Brazil. Luis.Becker@med.uni-heidelberg.de
Unlabelled:
The optimal immunosuppressive regimen for simultaneous kidney pancreas transplantation (SKPT) is still not established. We conducted a study to compare the safety and efficacy of no induction versus anti-IL-2 receptor induction protocols in SKPT recipients receiving the same maintenance regimen.
Methods:
Sixty-three SKPT recipients were divided into two groups: no induction group (n = 42) and anti-IL-2 receptor induction group (n = 21). All patients were maintained on tacrolimus, mycophenolate mofetil, and prednisone. Primary endpoints were 1-year acute rejection incidence and patient and graft survivals.
Results:
Demographic characteristics were similar between the groups. Acute rejection incidence at 1 year was equal in both groups (28.6%). Kidney and pancreas allograft survival in the no induction group were 78.6% and 76.2%, and in the anti-IL-2R induction group, 81% and 71.4%, respectively (P = NS). Patient survival was also similar: 83.3% in the no induction versus 85.7% in the anti-IL-2R induction group. Deaths due to sepsis were higher in the anti-IL-2R induction group, albeit not significantly.
Conclusion:
The use of a no-induction protocol in SKPT is safe and effective immunosuppression that also reduces transplantation costs.
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