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Published on: October 15, 2021
Clot removal therapy by aspiration and extraction for acute embolic carotid occlusion
1Department of Stroke Treatment, Shonan Kamakura General Hospital, 1201-1 Yamazaki Kamakura, Kanagawa 247-8533, Japan.
Insights
Clot removal therapy using a balloon guide catheter effectively restored blood flow in acute stroke patients with internal carotid artery occlusion. This technique showed promising results for favorable neurologic and functional outcomes.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Vascular Surgery
Background:
- Acute ischemic stroke due to internal carotid artery (ICA) occlusion presents a significant clinical challenge.
- Effective clot removal is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the feasibility, safety, and efficacy of aspiration and extraction clot removal therapy.
- Specifically focused on patients with embolic ICA occlusion.
Main Methods:
- Retrospective analysis of 14 patients with acute ischemic stroke and ICA occlusion.
- Inclusion criteria: within 6 hours of onset, NIHSS score ≥11, perfusion/diffusion mismatch, and total ICA occlusion.
- Clot removal performed using aspiration and extraction with a microsnare via guiding or balloon guide catheters.
Main Results:
- Balloon guide catheter use resulted in recanalization in 7 of 10 patients, while guiding catheters showed no recanalization.
- Six of 7 patients with recanalization achieved favorable 7-day neurologic and 3-month functional outcomes.
- One complication of distal embolization occurred.
Conclusions:
- Balloon guide catheter-assisted clot removal is a feasible and effective treatment for embolic ICA occlusion.
- This therapy offers high recanalization rates and good clinical outcomes, particularly in patients with adequate collateral circulation.
Background And Purpose:
The purpose of our retrospective study was to investigate the feasibility, safety, and efficacy of clot removal therapy by aspiration and extraction for patients with acute stroke with embolic internal carotid artery (ICA) occlusion.
Methods:
Of 814 consecutive patients with acute ischemic stroke admitted to our institution from March 2003 to April 2005, clot removal therapy was performed for 14. Inclusion criteria were patients (1) presenting within 6 hours of onset of cardioembolic stroke, (2) with serious neurologic symptoms defined by a National Institutes of Health Stroke Scale (NIHSS) score of at least 11, (3) without extensive high signal intensity on diffusion-weighted MR images but with decreased ipsilateral hemispheric cerebral blood flow on perfusion-weighted images (perfusion/diffusion mismatch), and (4) with total ICA occlusion on angiograms. We removed clots by aspiration and extraction with a microsnare through either a guiding or balloon guide catheter. Radiographic results, 7-day NIHSS, 3-month modified Rankin Scale, and procedure-related complications were evaluated.
Results:
Of 10 patients treated with the balloon guide catheter to temporarily interrupt proximal flow, 7 obtained complete or partial recanalization. The 4 patients treated with the guiding catheter had no recanalization. Of the 7 patients with recanalization, 6 had favorable 7-day neurologic and 3-month functional outcome; all showed anatomic crossflow via the anterior communicating artery. A procedure-related complication, distal embolization into the ipsilateral anterior cerebral artery, occurred in 1 patient.
Conclusion:
Balloon guide catheter-assisted clot removal therapy for embolic ICA occlusion may provide a high recanalization rate and good clinical outcome in patients with anatomic crossflow.
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