Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Excitotoxicity and amyotrophic lateral sclerosis.

P Van Damme1, M Dewil, W Robberecht

  • 1Neurobiology, Campus Gasthuisberg, Leuven, Belgium.

Neuro-Degenerative Diseases
|August 16, 2006
PubMed
Summary

Excitotoxicity, a key mechanism in amyotrophic lateral sclerosis (ALS), contributes to motor neuron death. Understanding this process may lead to new therapies protecting motor neurons.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A deep phenotyping study in mouse and iPSC models to understand the role of oligodendroglia in optic neuropathy in Wolfram syndrome.

Acta neuropathologica communications·2024
Same author

140&#x2003;Effect of lycopene supplementation to bovine oocytes exposed to heat shock during <i>in vitro</i> maturation.

Reproduction, fertility, and development·2022
Same author

Animal experiments show impact of vaccination on reduction of SARS-CoV-2 virus circulation: A model for vaccine development?

Biologicals : journal of the International Association of Biological Standardization·2021
Same author

Effect of lycopene supplementation to bovine oocytes exposed to heat shock during in vitro maturation.

Theriogenology·2021
Same author

Necrosome-positive granulovacuolar degeneration is associated with TDP-43 pathological lesions in the hippocampus of ALS/FTLD cases.

Neuropathology and applied neurobiology·2020
Same author

Amyotrophic lateral sclerosis: a clinical review.

European journal of neurology·2020

Area of Science:

  • Neuroscience
  • Pathology
  • Biochemistry

Background:

  • Amyotrophic lateral sclerosis (ALS) pathogenesis remains elusive despite over 130 years of study.
  • Multiple factors like oxidative stress, inflammation, and excitotoxicity are implicated in motor neuron degeneration.
  • Excitotoxicity is a robustly supported mechanism, potentially explaining the selective vulnerability of motor neurons.

Purpose of the Study:

  • To review evidence supporting excitotoxicity in ALS pathogenesis.
  • To explore mechanisms of motor neuron death due to excitotoxicity.
  • To identify motor neuron properties contributing to excitotoxicity vulnerability.

Main Methods:

  • Literature review of proposed pathogenic mechanisms in ALS.
  • Analysis of evidence supporting the excitotoxicity hypothesis.
  • Examination of riluzole's therapeutic effects and anti-excitotoxic properties.

Main Results:

  • Excitotoxicity is a well-supported pathogenic mechanism in ALS.
  • Riluzole's efficacy is likely linked to its anti-excitotoxic actions.
  • Specific motor neuron characteristics increase susceptibility to excitotoxicity.

Conclusions:

  • Excitotoxicity plays a significant role in the selective degeneration of motor neurons in ALS.
  • Further understanding of excitotoxicity mechanisms can guide the development of novel therapeutic strategies.
  • Targeting excitotoxicity offers a promising avenue for protecting motor neurons in ALS patients.

Related Experiment Videos