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[Cerebral involvement in Whipple's disease].

T Niederstadt1, B Beck, R Hunecke

  • 1Zentralröntgeninstitut des Städtischen Klinikums Karlsruhe.

Rofo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin
|March 1, 1990
PubMed
Summary

Whipple's disease rarely affects the brain. Computed tomography (CT) scans showed unspecific atrophy in one patient and hydrocephalus with a temporal lesion in another, highlighting the need for clinical data for diagnosis.

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Whipple's disease is a rare systemic infection with protean manifestations.
  • Cerebral involvement occurs in approximately 10% of patients, presenting diagnostic challenges.

Observation:

  • This study presents computed tomography (CT) findings in two patients with symptomatic cerebral Whipple's disease.
  • Patient 1 exhibited non-specific cerebral atrophy.
  • Patient 2 presented with hydrocephalus occlusus and a contrast-enhancing temporal lobe lesion.

Findings:

  • CT findings in cerebral Whipple's disease are often non-specific.
  • Imaging features can include atrophy, hydrocephalus, and contrast-enhancing lesions.
  • Distinguishing cerebral Whipple's disease solely on CT is difficult.

Implications:

  • Early recognition of potential neurological involvement in Whipple's disease is crucial.
  • CT findings, while suggestive, require integration with clinical data for accurate diagnosis.
  • Further research into specific neuroimaging biomarkers for cerebral Whipple's disease is warranted.

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