Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synapse development: still looking for the forest, still lost in the trees.

Craig C Garner1, Clarissa L Waites, Noam E Ziv

  • 1Department of Psychiatry and Behavioral Science, Nancy Pritzer Laboratory, Stanford University, Palo Alto, CA 94304-5485, USA. cgarner@stanford.edu

Cell and Tissue Research
|August 16, 2006
PubMed
Summary

Synapse development is a crucial, orchestrated process in the vertebrate central nervous system, vital for brain development and function throughout life. This process shapes neuronal connections, influencing learning and memory.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glucocorticoids regulate small extracellular vesicle release via activation of nSMase2.

Journal of cell science·2026
Same author

APOE4 exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction.

Cell death & disease·2026
Same author

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.

Nature communications·2026
Same author

Prevention of ubiquitination at K6 and K9 in mutant huntingtin exacerbates disease pathology in a knock-in mouse model.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A neuron type-specific microexon in <i>Ank3</i>/ankyrin-G modulates calcium activity and neuronal excitability.

bioRxiv : the preprint server for biology·2025
Same author

Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology.

Communications biology·2025

Area of Science:

  • Neuroscience
  • Developmental Biology

Background:

  • Synapse development is a complex, orchestrated process in the vertebrate central nervous system.
  • It occurs during early brain development and continues to a lesser extent in the mature nervous system.

Purpose of the Study:

  • To elucidate the intricate mechanisms of synapse formation, stabilization, and elimination.
  • To understand the linkage between synaptic plasticity and cognitive functions.

Main Methods:

  • This study focuses on the developmental and functional aspects of synaptic plasticity.
  • It integrates concepts from neurobiology and developmental processes.

Main Results:

  • Synapse formation is tightly linked to neuronal differentiation, axonal/dendritic extension, and nervous system wiring.

Related Experiment Videos

  • Synaptic stabilization, elimination, and strengthening correlate with arbor refinement and functional connection establishment.

    • Conclusions:

    • Synapse development is fundamental for establishing functional neural circuits.
    • Ongoing synaptic refinement in the mature nervous system likely supports memory, cognition, and behavior.