Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracellular monovalent ions as second messengers.

S N Orlov1, P Hamet

  • 1Centre de recherche, Centre hospitalier de l'Université de Montréal, (CHUM)-Hôtel-Dieu, Montreal, Quebec, Canada. sergei.n.orlov@umontreal.ca

The Journal of Membrane Biology
|August 16, 2006
PubMed
Summary

Monovalent ions, beyond maintaining membrane potential, act as crucial second messengers. Their modulation triggers cellular responses like altered enzyme activity and gene expression, upstream of calcium signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-rated health scores predict mortality among people with type 2 diabetes differently across three different country groupings: findings from the ADVANCE and ADVANCE-ON trials.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Survey of primary care physicians' views about breast and ovarian cancer screening for true BRCA1/2 non-carriers.

Journal of community genetics·2019
Same author

No evidence of excessive cancer screening in female noncarriers from <i>BRCA1/2</i> mutation-positive families.

Current oncology (Toronto, Ont.)·2017
Same author

No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects.

European journal of clinical pharmacology·2016
Same author

Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined stroke: consecutive survivors and population-based controls.

Atherosclerosis·2015
Same author

Celastrol protects ischaemic myocardium through a heat shock response with up-regulation of haeme oxygenase-1.

British journal of pharmacology·2014

Area of Science:

  • Cellular Physiology
  • Ion Transport Mechanisms
  • Molecular Signaling

Background:

  • Electrochemical gradients of monovalent ions are vital for fundamental cellular processes.
  • These ions influence membrane potential, cell volume, and nutrient uptake.
  • Classic roles involve pumps, carriers, and channels in maintaining cellular homeostasis.

Purpose of the Study:

  • To review the non-classical roles of monovalent ions in cellular regulation.
  • To highlight their function as second messengers in physiological concentration ranges.
  • To discuss their upstream signaling role compared to calcium.

Main Methods:

  • Literature review of existing research on monovalent ion function.
  • Analysis of studies demonstrating cellular responses to ion concentration changes.

Related Experiment Videos

  • Synthesis of data on ion signaling pathways.

    • Main Results:

    • Monovalent ion concentration modulation triggers diverse cellular responses.
    • These include alterations in enzyme activity, gene expression, and cell fate.
    • Monovalent ions act upstream of calcium and other signaling intermediates.
    • Their role as second messengers is established, though sensors are largely unknown.

    Conclusions:

    • Monovalent ions possess significant regulatory functions beyond established roles.
    • They act as critical second messengers in cellular signaling pathways.
    • Further research is needed to identify the molecular sensors for these ions.