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Updated: Aug 6, 2026

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
Published on: June 28, 2024
Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene
Mirjana Tosic1, Jurg Ott, Sandra Barral
1Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland. Mirjana.Tosic@chuv.ch
Abstract:
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
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