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Related Experiment Videos

NF-kappaB modulators from Valeriana officinalis.

Nadia J Jacobo-Herrera1, Nina Vartiainen, Paul Bremner

  • 1Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, UK.

Phytotherapy Research : PTR
|August 16, 2006
PubMed
Summary

Valeriana officinalis extract inhibits NF-kappaB (nuclear factor kappa B) and protects brain cells. Key compounds like acetylvalerenolic acid show significant anti-inflammatory and neuroprotective potential.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Natural Products Chemistry

Background:

  • Valeriana officinalis, a medicinal herb, is traditionally used for nervous tension and sleep disorders.
  • Its anti-inflammatory properties have been noted in traditional European medicine.
  • Nuclear factor kappa B (NF-kappaB) is a key regulator of inflammation and cellular responses.

Purpose of the Study:

  • To investigate the anti-inflammatory and neuroprotective effects of Valeriana officinalis extracts and isolated compounds.
  • To identify the specific compounds responsible for the observed bioactivities.

Main Methods:

  • Extraction of underground parts of Valeriana officinalis using ethyl acetate (EtOAc).
  • In vitro assays including IL-6/Luc assay on HeLa cells to assess NF-kappaB inhibition.

Related Experiment Videos

  • Primary brain cell cultures were used to evaluate protection against excitotoxicity.
  • Bioassay-guided fractionation to isolate active compounds.

    • Main Results:

    • The EtOAc extract of V. officinalis inhibited NF-kappaB activity and protected against excitotoxicity.
    • Three known sesquiterpenes were isolated: acetylvalerenolic acid (1), valerenal (2), and valerenic acid (3).
    • Compounds 1 and 3 demonstrated significant NF-kappaB inhibitory activity, with acetylvalerenolic acid reducing activity by 4% and valerenic acid by 25%.

    Conclusions:

    • Valeriana officinalis possesses compounds with significant NF-kappaB inhibitory and neuroprotective properties.
    • Acetylvalerenolic acid and valerenic acid are key active constituents contributing to these effects.
    • These findings support the traditional use of Valeriana officinalis and suggest its potential for treating inflammatory and neurological conditions.